Platelet rich fibrin and nanocrystalline hydroxyapatite: hope for regeneration in aggressive periodontitis: A novel clinical approach

Periodontists have been experimenting various modalities for regeneration in Aggressive periodontitis with varying degrees of success. Periodontal surgery along with platelet rich fibrin (PRF) has yielded promising results. The purpose of this clinical trial was to evaluate the surgical outcome of an autologous growth factor obtained by sequestering and concentrating platelets by gradient density centrifugation in periodontal regeneration in AgP. Three patients diagnosed as AgP were selected for this study. Baseline, clinical and radiographic examination were performed and patients were treated by surgical periodontal therapy along with PRF and nanocrystalline hydroxyapatite. Post-surgical, clinical and radiographic reevaluation were carried out at regular intervals to assess healing and radiographic changes. Surgical Periodontal debridement along with the placement of PRF in combination with nanocrystalline hydroxyapatite in angular defects of the subjects showed decreased probing pocket depth, gain in attachment level and radiographic bone fill as compared with the baseline. Because of the more favourable bony morphology of subjects with AgP and the ideal characteristics of PRF, reconstructive therapy along with PRF and hydroxyapatite in angular defects of AgP patients can be an effective approach for periodontal regeneration.